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《现代养猪生产技术》读者互动专区

《现代养猪生产技术》读者互动专区

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"组学技术"带来下一个水平的肠道健康革新

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kk 发表于 2016-8-22 15:33:48 | 显示全部楼层 |阅读模式
多个专业、先进的关于检测活组织内细胞代谢的研究,为未来动物生产中关于肠道健康、生长性能的真正创新奠定了基础。

De Cesare、Niewold教授及Waxenecker先生将在2016年10月12-15日在加拿大温哥华开展的“世界营养论坛”上关于“肠道健康和生长性能”主题上发表此研究,

对肠道健康和生长性能理解方面的突破,有助于规划未来营养策略和抗生素促生剂的替代品。
1 - 副本.jpg
目前进展

‘组学’领域的研究范围包括基因组学、转录组学、蛋白质组学和代谢组学。这些研究在畜牧科学日益得到重视,部分归因于它们同时适用于肠道微生物和宿主组织。 Biomin的开发总监Franz Waxenecker,指出。

基因组学通过对单个个体全基因组的测序,提供了大量的特殊基因序列数据。转录组学可以对转录后的mRNA进行定量,且将其翻译成核蛋白。蛋白质组学和代谢组学将进一步地检测翻译后的蛋白质和代谢物。

新认识

博洛尼亚大学的Alessandra De Cesare教授指出,宏基因组学测序可以帮助我们研究全部微生物的天然特性及其与宿主间的联系,这为靶向疾病、改善动物健康水平、目的营养策略等开启了一条新的通道。

抗生素促生剂的替代品

鲁汶大学Theo Niewold教授指出,利用‘组学技术’及简单的非侵入性的体内生物标记法,我们知道了生产动物的生长速度和健康与肠道炎症间存在相互影响。这样使成功选择有效的抗生素促生长剂的变得相对容易。尽管欧盟及其它地方已经多年停止使用抗生素促生长剂,但大部分生产者都将面对向无抗生产的转换。

超过30个国家已经禁止使用抗生素促生长剂,主要原因为人类健康及抗生素耐药性问题。许多还没有禁止使用的地方,也在呼吁无抗生产。Biomin.认为,在2010年至2030年,全球对畜牧生产中新型促生长剂的使用将会翻倍。

附原文:
'Omics' to bring next level gut health innovations

Several narrow, advanced fields of study that examine the cellular metabolism of living organisms are setting the foundations for genuine innovation relating to gut health and performance in animal production in the years ahead.

This statement is endorsed by experts Prof De Cesare, Prof Niewold and Mr Waxenecker, who will share their knowledge on this topic at the expert gut health and performance session of the 2016?World Nutrition Forum  in Vancouver, Canada on 12-15 October.

Breakthroughs in the understanding of gut health and performance may help define future nutrition strategies and the substitution of antibiotic growth promoters (AGPs)。

Gaining ground

“Areas of study including genomics, transcriptomics, proteomics and metabolomics, colloquially referred to as the '-Omics' fields, are gaining importance in livestock sciences, particularly because they are applicable to both the gut microbiome and the host tissue,” according to Franz Waxenecker, development director at Biomin.

Genomics through whole genome sequencing provides a huge amount of data on specific genetic traits (DNA sequences) of an individual, while transcriptomics allows the quantification of the mRNA after transcription and its potential translation in the ribosomes. Proteomics and metabolomics go one step further, measuring the translated proteins or metabolites.

New insights

“Shotgun metagenomic sequencing allows us to investigate whole populations of microorganisms in their natural habitats and in the context of their interrelationships with the host,” stated Prof Alessandra De Cesare of the University of Bologna. “This opens the door to new strategies to fight diseases and improve animal health, such as fit-for-purpose nutrition strategies,” she observed.

Alternatives to AGPs

“Using '-Omics' techniques and simple non-invasive biomarkers in vivo, we now know that growth and health in production animals is reciprocal to intestinal inflammation,” explained Prof Theo Niewold of KU Leuven, adding that “this makes it relatively easy to successfully select effective alternatives to AGPs.” While producers in the European Union and elsewhere ceased AGP use years ago, in many countries producers still face the transition to antibiotic-free production.

Over 30 countries have already banned the use of antibiotic growth promoters, mainly due to concerns about human health and the emergence of bacteria resistant to multiple types of antibiotics. Many places where their use is not banned have seen a surge in demand for antibiotic-free products. Worldwide, use of novel growth promoters in livestock production is expected to more than double between 2010 and 2030, according to Biomin.

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